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desvenlafaxine will increase the degree or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by approximately 50%; no dosage adjustment required with desvenlafaxine doses 7 consecutive times right a